Definitiv Professional
| League 1 | 29/11/2025 | Burton | 15:00 | Leyton Orient | Pirelli Stadium | |||
| FA Cup | 05/12/2025 | Salford City | 19:30 | Leyton Orient | Moor Lane | |||
| League 1 | 09/12/2025 | Leyton Orient | 19:45 | Luton | BetWright Stadium | |||
| League 1 | 13/12/2025 | Barnsley | 15:00 | Leyton Orient | Oakwell | |||
| League 1 | 20/12/2025 | Leyton Orient | 15:00 | Bradford | BetWright Stadium | |||
| League 1 | 26/12/2025 | Peterborough | 15:00 | Leyton Orient | Weston Homes Stadium | |||
| League 1 | 29/12/2025 | Luton | 19:45 | Leyton Orient | Kenilworth Road | |||
| League 1 | 01/01/2026 | Leyton Orient | 15:00 | AFC Wimbledon | BetWright Stadium | |||
| League 1 | 04/01/2026 | Stevenage | 15:00 | Leyton Orient | Lamex Stadium | |||
| League 1 | 10/01/2026 | Leyton Orient | 15:00 | Cardiff | BetWright Stadium |
| League 1 | 22/11/2025 | Leyton Orient | 1 1 | Blackpool | |||
| League 1 | 15/11/2025 | Leyton Orient | 2 1 | Exeter City | |||
| League 1 | 08/11/2025 | Wycombe | 4 1 | Leyton Orient | |||
| FA Cup | 03/11/2025 | Tamworth | 0 1 | Leyton Orient | |||
| League 1 | 25/10/2025 | Leyton Orient | 1 0 | Lincoln City | |||
| League 1 | 18/10/2025 | Rotherham | 1 0 | Leyton Orient | |||
| League 1 | 11/10/2025 | Leyton Orient | 4 0 | Doncaster Rovers | |||
| League 1 | 04/10/2025 | Cardiff | 4 3 | Leyton Orient | |||
| League 1 | 27/09/2025 | Leyton Orient | 2 3 | Stevenage | |||
| League 1 | 20/09/2025 | Reading | 2 1 | Leyton Orient |
| pos | club | w | d | l | gf | ga | gd | pts | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Stevenage | 9 | 3 | 3 | 19 | 11 | 8 | 30 | |
| 2 | Cardiff | 9 | 2 | 4 | 25 | 15 | 10 | 29 | |
| 3 | Bradford | 7 | 7 | 2 | 24 | 18 | 6 | 28 | |
| 4 | Lincoln City | 8 | 4 | 5 | 22 | 18 | 4 | 28 | |
| 5 | Stockport | 8 | 4 | 4 | 22 | 20 | 2 | 28 | |
| 6 | Bolton | 7 | 6 | 3 | 23 | 15 | 8 | 27 | |
| 7 | Luton | 8 | 2 | 7 | 20 | 21 | -1 | 26 | |
| 8 | Huddersfield | 8 | 1 | 7 | 25 | 22 | 3 | 25 | |
| 9 | AFC Wimbledon | 8 | 1 | 7 | 20 | 22 | -2 | 25 | |
| 10 | Barnsley | 7 | 3 | 4 | 25 | 18 | 7 | 24 | |
| 11 | Wycombe | 6 | 5 | 6 | 25 | 19 | 6 | 23 | |
| 12 | Rotherham | 6 | 5 | 6 | 19 | 19 | 0 | 23 | |
| 13 | Mansfield | 6 | 4 | 6 | 23 | 20 | 3 | 22 | |
| 14 | Burton | 6 | 4 | 6 | 16 | 19 | -3 | 22 | |
| 15 | Wigan | 5 | 6 | 5 | 20 | 20 | 0 | 21 | |
| 16 | Leyton Orient | 6 | 3 | 8 | 25 | 29 | -4 | 21 | |
| 17 | Northampton Town | 6 | 2 | 8 | 13 | 17 | -4 | 20 | |
| 18 | Reading | 4 | 7 | 5 | 17 | 20 | -3 | 19 | |
| 19 | Doncaster Rovers | 5 | 4 | 8 | 15 | 23 | -8 | 19 | |
| 20 | Exeter City | 5 | 2 | 9 | 16 | 17 | -1 | 17 | |
| 21 | Peterborough | 5 | 1 | 10 | 18 | 23 | -5 | 16 | |
| 22 | Blackpool | 4 | 4 | 9 | 17 | 25 | -8 | 16 | |
| 23 | Plymouth | 5 | 1 | 10 | 19 | 28 | -9 | 16 | |
| 24 | Port Vale | 3 | 5 | 9 | 11 | 20 | -9 | 14 |